PREVALENCE OF HYPERGLYCEMIA IN HIV PATIENTS ON DOLUTEGRAVIR ART REGIMEN RECEIVING CARE AT JINJA REGIONAL REFERRAL HOSPITAL. A CROSS-SECTIONAL STUDY.

Abstract

Background 

Emerging evidence suggests a possible association between hyperglycemia and dolutegravir (DTG), preferred first-line antiretroviral agents in sub-Saharan Africa (SSA). In Zambia, DTG DTG-based ART was associated with more double risk of developing metabolic syndrome among HIV patients with metabolic syndrome including hyperglycemia. .The study aims to determine the Prevalence of hyperglycemia in HIV patients on a Dolutegravir ART regimen. receibyving care at Jinja Regional Referral Hospital.

Methodology

A cross-sectional study was designed at Jinja Regional Referral Hospital located in Jinja City, Eastern Uganda with a total of 96 respondents. It included all adult PLWHIV initiated on a Dolutegravir-based ART regimen attending the ART clinic at JRRH.

Results 

The prevalence of hyperglycemia was 19.8% among adult HIV patients on the Dolutegravir ART regimen receiving care at Jinja Regional Referral Hospital. 19/96 (19.8%) participants had high blood sugar levels above the normal henceforth and 77/96 (80.2%) of the participants had normal fasting blood sugar. majority 45(46.9%) of the respondents were in the age group of 46-60years with hyperglycaemia prevalence of 9(47.4%). majority of the respondents 53(55.2%) were males with 11(57.9%) prevalence and the minority 43(44.8%) were females with hyperglycaemia prevalence of 8(42.1%). majority 46(47.9%) of the respondents attended secondary school education with a prevalence of 8(42.1%),

Conclusion

Hyperglycemia is prevalent in Retroviral infection patients on a Dolutegravir-containing ART regimen and the drug is associated with weight changes.

Recommendation

Patients on Dolutegravir should be sensitized and monitored for weight changes and symptoms of hyperglycemia for early diagnosis and treatment for hyperglycemia and other metabolic derangements.